Histamine, migraines and gut microbiome.

Reducing excess histamine can improve migraines, heart health, breathing, and skin conditions. One way to solve histamine issues is to maximize histamine detox. The most significant histamine reducers are the enzymes DAO and HNMT.

Copper, vitamin B6 (as P5P), and vitamin C are the main cofactors for the production of DAO. Sometimes, correcting a bottleneck in just one of these is helpful.

Getting more vitamin C from acerola powder was significant for me. 1.5g of acerola powder contains 500 mg of vitamin C, and unlike ascorbic acid, it does not cause me irritation (increasing histamine). I saw improvements in sleep and skin irritation, both histamine-related.

Wearing copper bracelets is likely to absorb a significant amount of copper.

Supplementing the P5P form might be better than the pyridoxine form. [Either can cause reversible neuropathy, especially at high doses.] 

5-10 mg P5P works well for me, in general.

DAO supplements can be very useful for people with high histamine. DAO breaks down histamine, particularly in the digestive tract, and is decreased by magnesium deficiency.

Magnesium deficiency also increases histamine, and supplementing to fix the deficiency lowers histamine.

HDC creates histamine and it is increased by mag deficiency. 

Cyproheptadine is a great anti-histamine.

Caffeine inhibits histamine release from mast cells and reduces mortality from anaphylactic shock. 

Vitamin B1 deficiency increases histamine, and fixing the deficiency lowers histamine.

L-theanine is a mast cell stabilizer that can reduce anaphylactic shock. Doses for anxiety tend to be around 250 mg, but some folks need 1-1.5g for antihistamine effects.

The tocotrienol form of vitamin E (T3) reduces dermatitis by stabilizing mast cells and decreasing histamine release. Tocotrienol and other forms of vitamin E reduce lipid peroxidation - the oxidative conversion of polyunsaturated fatty acids into more inflammatory byproducts. Lipid peroxidation byproducts like 4-HNE cause mast cell degranulation, releasing histamine and serotonin.

Common causes of elevated histamine include 

1. high estrogen, 
2. endotoxin, 
3. hypothyroidism, 
4. high parathyroid hormone, 
5. endorphins, 
6. opiates, 
7. opioids, 
8. polyunsaturated fatty acids (n-3 and n-6), 
9. calcium deficiency, 
10. hypoglycemia, 
11. elevated free fatty acids, and 
12. lipid peroxidation.

 

𝘏𝘪𝘴𝘵𝘢𝘮𝘪𝘯𝘦 𝘪𝘴 𝘪𝘮𝘱𝘭𝘪𝘤𝘢𝘵𝘦𝘥 𝘪𝘯 

1. 𝘐𝘉𝘚, 
2. 𝘐𝘉𝘋, 
3. 𝘢𝘵𝘩𝘦𝘳𝘰𝘴𝘤𝘭𝘦𝘳𝘰𝘴𝘪𝘴, 
4. 𝘰𝘴𝘵𝘦𝘰𝘢𝘳𝘵𝘩𝘳𝘪𝘵𝘪𝘴, 𝘳𝘩𝘦𝘶𝘮𝘢𝘵𝘰𝘪𝘥 𝘢𝘳𝘵𝘩𝘳𝘪𝘵𝘪𝘴, 
5. 𝘩𝘦𝘢𝘳𝘵 𝘥𝘪𝘴𝘦𝘢𝘴𝘦, 𝘩𝘦𝘢𝘳𝘵 𝘧𝘢𝘪𝘭𝘶𝘳𝘦, 𝘶𝘯𝘴𝘵𝘢𝘣𝘭𝘦 𝘢𝘯𝘨𝘪𝘯𝘢, 𝘩𝘦𝘢𝘳𝘵 𝘢𝘵𝘵𝘢𝘤𝘬𝘴, 
6. 𝘴𝘵𝘳𝘰𝘬𝘦, 
7. 𝘷𝘪𝘳𝘢𝘭 𝘪𝘭𝘭𝘯𝘦𝘴𝘴𝘦𝘴, 
8. 𝘢𝘭𝘭𝘦𝘳𝘨𝘪𝘦𝘴, 𝘩𝘢𝘺 𝘧𝘦𝘷𝘦𝘳, 𝘢𝘴𝘵𝘩𝘮𝘢, 
9. 𝘶𝘭𝘤𝘦𝘳𝘴, 𝘥𝘪𝘢𝘳𝘳𝘩𝘦𝘢, 
10. 𝘧𝘪𝘣𝘳𝘰𝘴𝘪𝘴, 𝘢𝘯𝘥 𝘪𝘯𝘧𝘭𝘢𝘮𝘮𝘢𝘵𝘪𝘰𝘯.

from

Reducing excess histamine can improve migraines, heart health, breathing, and skin conditions.

https://x.com/lowmegatron/status/1877065455141114081

Histamine Hacks https://x.com/lowmegatron/status/1876328764310794304

Things that can lower or block serotonin:

> Aspirin - lowers plasma serotonin

> L-theanine - lowers brain serotonin

> Thiamine - lowers brain serotonin (in deficiency)

> Glycine - lowers brain serotonin

> Taurine - lowers brain serotonin

> Thyroid hormone T3 - lowers brain and nonbrain serotonin (in hypothyroidism)

> Ginger - lowers brain and non-brain serotonin, serotonin synthesis, and blocks serotonin

> Cyproheptadine - blocks serotonin

> Negative air ions - likely decrease brain and non-brain serotonin

> Vitamin E - lowers brain serotonin

> Magnesium - lowers brain serotonin (in deficiency)

> DHEA - blocks stress-induced serotonin synthesis (higher doses are estrogenic/bad)

> Avoiding seed oils - the linoleic acid increases blood serotonin

> Eating regularly - prevents excess linoleic acid in the blood

> Lysine - blocks serotonin 5-HT4 receptor (GI and mental function)

> Progesterone - inhibits serotonin synthesis

> Testosterone/DHT - inhibit serotonin synthesis

https://x.com/lowmegatron/status/1912957173719515291

Thymus, Tcells, Zinc and immunity

> The thymus is the primary organ of the immune system

> It shrinks with age, increased cortisol, starvation, and dietary PUFA

> It can be revitalized with aromatase inhibitors, including zinc

> Zinc reduces infection rates in older people

“It is therefore possible to restore the thymus in intact aging rats without recourse to surgical or chemical castration.”

“Aging-related physiological zinc deficiency induces some relevant changes in thymus structure and function which can be partially corrected by a mild oral zinc supplementation.”

"Cortisol treatment resulted, within two days, in a loss of lymphocytes (in thymus) and a rise in the proportion of macrophages and fibroblasts. This pattern was similar to that characteristic of old thymus, except that the loss of lymphocytes was greater after cortisol injection and there was no increase in collagen.”

“Our study showed that zinc supplementation administered to the elderly population resulted in a significant decrease in the incidence of infection.”

“Zinc deficiency, cell-mediated immune dysfunction, susceptibility to infections, and increased oxidative stress have been observed in elderly subjects.” 

“Many animal studies show that zinc deficiency decreases resistance to a range of bacterial, viral, fungal, and parasitic pathogens, probably because of the immune impairment induced by zinc deficiency.” 

stress damages organs

from https://x.com/lowmegatron/status/1898400973619367999

Endotoxins

 Some things that can help with endotoxin:

* Vitamin E reduces endotoxin-induced inflammation.

* Vitamin D helps seal the gut and reduces inflammation caused by endotoxin.

* Vitamin C reduces inflammation and endotoxin leakage into the system from the gut.

* Aspirin decreases the inflammatory response to endotoxin.

* Inadequate sleep and circadian disorganization increase endotoxin.

* Activated charcoal adsorbs endotoxin. However, chronic use is generally to be avoided.

* Citrus flavonoids like naringenin reduce endotoxin-induced inflammation.

* Some probiotics can reduce endotoxin.

* Promising candidates include Bacillus indicus (HU36), Bacillus subtilis (HU58), Bacillus coagulans, Bacillus licheniformis, Mutaflor, Biosporin, and Bacillus clausii.

* Oxytocin reduces the inflammatory response to endotoxin.

* Benfotiamine, a form of vitamin B1, reduces endotoxic inflammation.

* Vitamin K2 and K1 can protect the testicles from endotoxin damage.

* Glycine has numerous protective effects.

* It is also found in collagen and gelatin.

* Coffee protects against inflammation and absorption of endotoxin.

* By increasing peristalsis, coffee can reduce constipation-related endotoxemia.

* Aged cascara sagrada can also increase peristalsis, reducing endotoxin.

* It also has compounds that reduce bacterial inflammation.

* Well-cooked mushrooms can also help to clear endotoxins from the gastrointestinal system and reduce inflammation.

* Progesterone binds endotoxin and reduces inflammation.

* Zinc is essential for a healthy gut barrier - keeping endotoxin out of general circulation.

* Zinc L-carnosine is particularly effective at regenerating a degraded gastrointestinal barrier.

* Finally, gut and thyroid problems will increase endotoxemia, so fixing those is essential.

https://x.com/lowmegatron/status/1891201018571964523

one knowledgeable person (sekhar) advised

zinc - L - carnosine + lactoferrin + triphala + yastimadhu ....for gut healing....👌👍😊

1 night of sleep deprivation

1 night of sleep deprivation: 

- reduces muscle protein synthesis by 18%

- increases cortisol by 21% 

- drops testosterone by 24%, promoting muscle breakdown.

Similar breakdowns happen as well with prolonged sleep exhaustion (less than 4hrs per night for 5 nights)